NanoHealer will realize a sprayable multifunctional nanofibrous hydrogel for skin injury therapy by merging the properties of bioactive nanofibrous platforms and stimuli-responsive nanomaterials. The goal of the presented project is to develop a stimuli-responsive bioactive wound dressing which can fulfill the main treatment requirements for curing infected wounds. The final material will be a sprayable plasmonic hydrogel nanocomposite that guarantees the necessary breathability and mechanical support. Moreover, the spray-on skin product will provide the supply of several targeted therapies, including Chemo and Stem Cell therapy, to simultaneously eradicate infections and repair the skin tissue. Additionally, drug release and photothermal therapy can be simultaneously achieved and modulated upon stimulation. This therapeutic approach has recently received enormous attention in the biomedical field. Indeed, it has several advantages which are crucial for performing effective wound treatments, such as spatiotemporal control, minimal invasiveness, and high drug selectivity.

The new nanomaterials will be fabricated using an innovative method involving the combination of various techniques (e.g. electrospinning, milling, wet chemistry and in-situ photopolymerization) and the employment of different healing approaches (e.g. bacterial disinfection, on-demand multidrug delivery and stem cell therapy). The hydrogels will be researched and characterized using several testing methods to prove their outstanding properties and demonstrate their on-demand triggered functionalities. Finally, the unique functionalities of the developed sprayable hydrogel will be verified by both in vitro and in vivo experiments.

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The project will be completed by the cooperation between the Institute of Fundamental Technological Research of Polish Academy of Sciences (IPPT) and Donghua University.

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